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ea0007oc37 | Diabetes and metabolism | BES2004

Resistin as an acute phase reactant and a positive mediator of IL-6 and TNF-alpha secretion in isolated human subcutaneous adipocytes

Kusminski C , McTernan P , Fisher F , Valsamakis G , Chetty R , Harte A , Kumar S

Chronic sub-clinical inflammation is associated with both type 2 diabetes and related vascular complications which is coupled with pro-inflammatory markers, such as IL-6, TNF-alpha and C-reactive protein (CRP). Resistin is the latest protein to be linked with inflammation and insulin resistance in obesity. Adipose tissue has been previously established as a source of circulating resistin, TNF-alpha and IL-6. As our previous studies demonstrated a correlation between serum resi...

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ea0015oc18 | Tumours, diabetes, bone | SFEBES2008

Human omental adipose tissue as a key site for the inflammatory 15-lipoxygenase pathway: Implications for metabolic disease

Hill Margaret J , McTernan Philip G , da Silva Nancy F , McGee Kirsty C , Kusminski Christine M , Baker Adam R , Kumar Sudhesh , Harte Alison L

Materials and methods: Paired AbSc and Om AT were collected from patients undergoing elective liposuction surgery (Age; 45±1.72 years; lean BMI; 22.91±0.56 kg/m2; obese BMI; 33.51±1.04 kg/m2; n=23) for gene expression analysis by microarray and real time polymerase chain reaction (PCR). Fasted blood was taken to measure metabolic parameters.Results: Microarray data showed that Om AT had signi...

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Endocrine Abstracts

Resistin as an acute phase reactant and a positive mediator of IL-6 and TNF-alpha secretion in isolated human subcutaneous adipocytes

Human omental adipose tissue as a key site for the inflammatory 15-lipoxygenase pathway: Implications for metabolic disease

BiosciAbstracts